If you have special news to share, please email Dr. Wang (email: gwang@unmc.edu).
2025
Nov 26, 2025: lipid nanoparticle delivered AMP coding mRNA to combat lung infection.
Aug 6, 2025: TMcins is a new type of transmembrane helix-containing AMP (bacteriocin) that forms a large pore in membranes.
June 4, 2025: New family of antibiotics derived from the body's own proteins. AMPs, hidden in known protein sequences (i.e., encrpted AMPs), may be released to help combat infection in vivo and developed into new antibiotics.
May 15, 2025: How bacteria fight back against promising antimicrobial peptide. Note that TAT-RasGAP317-326 (see AP2980 in the APD) is a designed hybrid peptide which differs from natual membrane-targting peptides. According to the APD6, peptides that developed resistance tend to have lower hydrophobic ratio.
Feb 3, 2025: Generative AI pipeline creates promising antimicrobial peptides for screening.
2024
Aug 01, 2024: dmSLAY library screening: the closer to natural AMPs, the better
July 03, 2024: AMP mixtures: too many bullets to dodge for resistant pathogens
June 11, 2024: Cyclic peptides to fight AMR
June 05, 2024: AI predction: largest-ever antimicrobial sequence discovery from biosphere
May 02, 2024: Cow AMPs can treat incurable bacteria infection
2023
Dec 22, 2023: Scorpion venom peptides inhibit SARS-CoV-2 at IC50 of 200 nM. See AP03940
May 2023: Novel Polymyxin-Inspired Peptidomimetics Targeting the SARS-CoV-2 Spike:hACE2 Interface
2022
Nov 15, 2022: In silico identification of SARS-Cov-2 peptide inhibitors
Oct 22, 2022: Vitamin D enhances type I IFN signaling in COVID-19 patients
April 25, 2022: Improved database filtering technology succeeded in designing ab initio antiviral peptides against Zika viruses and SARS-Cov-2
2021
June 26, 2021: Human defensins HNPs1-3, HD5, and a theta-defensin RC101 inhibit SARS-COV2 via blocking viral entry
2020
May 28, 2020: Vitamin D deficiency and air pollution worsen COVID-19 due to suppressing LL-37
May 11, 2020: Expression of LL-37 to treat COVID-19 patients (Not reviewed manuscript)
April 1, 2020: Lectin-like Intestinal Defensin HD5 Inhibits 2019-nCoV (SARS-CoV2) Spike binding to the ACE2 receptor (unreviewed report)
March 22, 2020: Engineered human cathelicidin LL-37 peptides inhibit Ebola virus infection
March 3, 2020: Opossum Cathelicidins Exhibit Activity Against West Nile Virus
Jun 17, 2019: Low cationicity is important for systemic in vivo efficacy of database designed peptides against MRSA
Jan 10, 2018: A new gel against deadly, drug-resistant superbugs
Jan 10, 2018: LL-37 inhibits Zika virus
April 21, 2017: Frog Urumin against influenza A virus H1N1
April 17, 2017: Potential Antibiotic from a Dragon's Blood
April 3, 2017: Strategy to enhance activity
Nov. 4, 2016: New AMP kills resistant strains
Sept 22, 2016: Plant AMPs Targets Dental Plaque and Gum Tissues
Jan 5, 2015: Fat Isn't All Bad
Nov 2009: RTD-1 prevents mouse death infected with SARS-CoV
Nov 2007: Human cathelicidin LL-37 inhibits HIV-1