Antimicrobial Peptide Database
The Antimicrobial Peptide Database (APD) contains 3324 antimicrobial peptides from six life kingdoms (391 bacteriocins/peptide antibiotics from bacteria, 5 from archaea, 8 from protists, 22 from fungi, 364 from plants, and 2446 from animals, including some synthetic peptides) with the following activity:

This original database for antimicrobial peptides is manually curated based on a set of data-collection criteria. There are 146 human host defense peptides, 339 from mammals annotated, 1135 active peptides from amphibians (1057 from frogs and 74 from toads), 141 fish peptides, 45 reptile peptides, 43 from birds, 585 from arthropods, [326 from insects, 72 from crustaceans, 8 from myriapods, 179 from chelicerata, (44 from spiders, 91 from scorpions)], 46 from molluscs, 6 AMPs from protozoa, and more.

Of the 447 unique NMR/X-ray diffracted 3D structures annotated for host defense peptides in the APD, 320 with coordinates deposited in the Protein Data Bank (PDB) can be directly rotated, zoomed, and viewed. Top left: Amphibian α-helical magainin II; Top right: bovine β-sheet lactoferricin; Bottom left: plant αβ-PsD1; Bottom right: bovine non-αβ indolicidin.

This comprehensive database consists of a pipeline of search functions for innate immune peptides. You can search for peptide information using APD ID, peptide name, amino acid sequence, peptide motif, chemical modification, length, charge, hydrophobic content, PDB ID, 3D structure, methods for structural determination, peptide source organism, peptide family name, life domain/kingdom (bacteria, archaea, protists, fungi, plants, animals), biological activity (see the links above), synergistic effects, target microbes, molecular targets, mechanism of action, contributing authors, and year of publication.


[1] Wang, G., Li, X. and Wang, Z. (2016) APD3: the antimicrobial peptide database as a tool for research and education. Nucleic Acids Research 44, D1087-D1093. Paper PDF
[2] Wang, G., Li, X. and Wang, Z. (2009) APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Research 37, D933-D937. Paper PDF
[3] Wang, Z. and Wang, G. (2004) APD: the antimicrobial peptide database. Nucleic Acids Research 32, D590-D592. Paper PDF
Last updated: Jan 6, 2022 | Copyright 2003-2022 Dept of Pathology & Microbiology, UNMC, All Rights Reserved

Number of visitors: 24755457