The Antimicrobial Peptide Database (APD) contains 2493 antimicrobial peptides (244 bacteriocins from bacteria, 2 from archaea, 7 from protists, 13 from fungi, 312 from plants, and 1874 from animals) with the following activity:
A comprehensive AMP database resource manually curated based on a set of data-collection criteria (see About).
Antiviral Peptides (Anti-HIV Peptides)
There are 108 human host defense peptides, 981 active peptides from amphibians, 83 fish peptides, 14 reptile peptides, 36 from birds, 382 from arthropods, 111 from chelicerata, 36 from crustaceans, 4 from myriapods, 231 from insects (e.g. lucifensin), 33 from spiders, 51 from scorpions, and more.
Of the 334 unique 3D structures annotated in the APD, 228 with coordinates deposited in the Protein Data Bank (PDB) can be rotated, zoomed, and viewed. Top left: Amphibian magainin II; Top right: bovine lactoferricin; Bottom left: plant PsD1; Bottom right: bovine indolicidin.
This database consists of a pipeline of search functions. You can search for peptide information using APD ID, peptide name, amino acid sequence, peptide motif, chemical modification, length, charge, hydrophobic content, PDB ID, 3D structure, methods for structural determination, peptide source organism, peptide family name, life domain/kingdom (bacteria, archaea, protists, fungi, plants, animals), biological activity (see the links above), synergistic effects, target microbes, molecular targets, mechanism of action, contributing authors, and year of publication.
In addition, you can access the APD Peptide Calculator here.
CITE: . Wang, G., Li, X. and Wang, Z. (2009) APD2: the updated antimicrobial peptide database and its application in peptide design.
Nucleic Acids Research 37, D933-D937. Paper PDF
. Wang, Z. and Wang, G. (2004) APD: the antimicrobial peptide database.
Nucleic Acids Research 32, D590-D592.] Paper PDF