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The Antimicrobial Peptide Database (APD) contains 2457 antimicrobial peptides (244 bacteriocins from bacteria, 2 from archaea, and 2170 from eukaryota [7 from protists, 13 from fungi, 311 from plants, and 1839 from animals]) with the following activity:
Antibacterial Peptides
Antiviral Peptides (Anti-HIV Peptides)
Antifungal Peptides
Antiparasitic Peptides (Antimalarial peptides)
Anticancer Peptides
Anti-protist Peptides
Insecticidal Peptides
Spermicidal Peptides
Chemotactic peptides
Antioxidant peptides
Protease inhibitors
A comprehensive AMP database resource manually curated based on a set of data-collection criteria (see About).
There are 108 human host defense peptides, 949 active peptides from amphibians, 80 fish AMPs, 14 reptile AMPs, 36 from birds, 382 from arthropods, 111 from chelicerates, 36 from crustaceans, 4 from myriapods, 230 from insects (e.g. lucifensin), 33 from spiders, 51 from scorpions, and more.

Of the 330 unique 3D structures annotated in the APD, 219 with coordinates deposited in the PDB can be rotated, zoomed, and viewed. Top left: Amphibian magainin II; Top right: bovine lactoferricin; Bottom left: plant PsD1; Bottom right: bovine indolicidin.

This database consists of a pipeline of search functions. You can search for peptide information using APD ID, peptide name, amino acid sequence, peptide motif, chemical modification, length, charge, hydrophobic content, PDB ID, 3D structure, methods for structural determination, peptide source organism, peptide family name, life domain/kingdom (bacteria, archaea, protists, fungi, plants, animals), biological activity (see the links above), synergistic effects, target microbes, molecular targets, mechanism of action, contributing authors, and year of publication.
In addition, you can access the APD Peptide Calculator here.

CITE: [1]. Wang, G., Li, X. and Wang, Z. (2009) APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Research 37, D933-D937. Paper PDF
[2]. Wang, Z. and Wang, G. (2004) APD: the antimicrobial peptide database. Nucleic Acids Research 32, D590-D592.] Paper PDF

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Last updated: Dec 2014 | Copyright 2003-2014 Dept of Pathology & Microbiology, UNMC, All Rights Reserved
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