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The Antimicrobial Peptide Database (APD) contains 2427 antimicrobial peptides (237 bacteriocins, 6 protozoan antibacterial peptides, 12 fungal AMPs, 309 plant AMPs, and 1819 animal host defense peptides) with the following activity:
Antibacterial Peptides
Antiviral Peptides
Antifungal Peptides
Antiparasitic Peptides
Anticancer/tumor Peptides
Anti-protist Peptides
Insecticidal Peptides
Spermicidal Peptides
Anti-HIV-1 Peptides
AMPs with chemotactic activity
A comprehensive AMP database resource manually curated based on a set of data-collection criteria (see About).
There are 945 antimicrobial peptides from amphibians, 79 from fish, 14 from reptiles, 36 from birds, 230 from insects, 33 from spiders, 33 from crustaceans, and more.

320 unique 3D structures are annotated. Over 200 with coordinates deposited in the PDB can be rotated, zoomed, and viewed.Top left: Amphibian magainin II;Top right: bovine lactoferricin;Bottom left: plant PsD1;Bottom right: bovine indolicidin.

This database consists of a pipeline of search functions. You can search for peptide information using APD ID, peptide name, amino acid sequence, peptide motif, chemical modification, length, charge, hydrophobic content, PDB ID, 3D structure, methods for structural determination, peptide source organism, peptide family name, life domains (bacteria, protozoan, fungi, plants, animals), antimicrobial activities (see links above), synergistic effects, target microbes, molecular targets, mechanism of action, contributing authors, and year of publication.
In addition, you can access the APD Peptide Calculator here.

CITE: 1. Wang, G., Li, X. and Wang, Z. (2009) APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Research 37, D933-D937. Paper PDF
2. Wang, Z. and Wang, G. (2004) APD: the antimicrobial peptide database. Nucleic Acids Research 32, D590-D592.] Paper PDF

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Last updated: Aug 2014 | Copyright 2003-2014 Dept of Pathology & Microbiology, UNMC, All Rights Reserved
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