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The Antimicrobial Peptide Database (APD) contains 2585 antimicrobial peptides from six kingdoms (258 bacteriocins from bacteria, 4 from archaea, 7 from protists, 13 from fungi, 320 from plants, and 1942 from animals) with the following activity:
Antibacterial Peptides (Antibiofilms)
Antiviral Peptides (Anti-HIV)
Antifungal Peptides
Antiparasitic Peptides (Antimalaria)
Anticancer Peptides
Anti-protist Peptides
Insecticidal Peptides
Spermicidal Peptides
Chemotactic peptides
wound healing
Antioxidant peptides
Protease inhibitors
This comprehensive AMP database resource is manually curated based on a set of data-collection criteria (see About).
There are 111 human host defense peptides, 989 active peptides from amphibians, 91 fish peptides, 18 reptile peptides, 36 from birds, 424 from arthropods, 132 from chelicerata, 36 from crustaceans, 6 from myriapods, 251 from insects, 42 from spiders, 63 from scorpions, 32 from molluscs; and more. A Unified Peptide Classification

Of the 350 unique 3D structures annotated in the APD, 235 with coordinates deposited in the Protein Data Bank (PDB) can be directly rotated, zoomed, and viewed. Top left: Amphibian magainin II; Top right: bovine lactoferricin; Bottom left: plant PsD1; Bottom right: bovine indolicidin. 3D Structure Classification

This popular database consists of a pipeline of search functions. You can search for peptide information using APD ID, peptide name, amino acid sequence, peptide motif, chemical modification, length, charge, hydrophobic content, PDB ID, 3D structure, methods for structural determination, peptide source organism, peptide family name, life domain/kingdom (bacteria, archaea, protists, fungi, plants, animals), biological activity (see the links above), synergistic effects, target microbes, molecular targets, mechanism of action, contributing authors, and year of publication.
Antimicrobial Peptides in 2014

CITE: [1]. Wang, G., Li, X. and Wang, Z. (2009) APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Research 37, D933-D937. Paper PDF
[2]. Wang, Z. and Wang, G. (2004) APD: the antimicrobial peptide database. Nucleic Acids Research 32, D590-D592. Paper PDF

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Last updated: July 28, 2015 | Copyright 2003-2015 Dept of Pathology & Microbiology, UNMC, All Rights Reserved
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