The Antimicrobial Peptide Database (APD) contains 2852 antimicrobial peptides from six kingdoms (304 bacteriocins/peptide antibiotics from bacteria, 4 from archaea, 8 from protists, 13 from fungi, 342 from plants, and 2181 from animals) with the following activity (Total AMPs: 2928):
Antibacterial peptides; Antibiofilm peptides
This comprehensive database for antimicrobial peptides is manually curated based on a set of data-collection criteria.
There are 123 human host defense peptides, 220 from mammals annotated, 1049 active peptides from amphibians (980 from frogs), 117 fish peptides, 35 reptile peptides, 40 from birds, 509 from arthropods, [287 from insects, 55 from crustaceans, 7 from myriapods, 160 from chelicerata, (43 from spiders, 77 from scorpions)], 42 from molluscs, 6 AMPs from protozoa, and more.
Antiviral peptides; Anti-HIV peptides
Antiparasitic peptides; Antimalarial peptides
Surface immobilized peptides
Wound healing peptides
Of the 390 unique 3D structures annotated for host defense peptides in the APD, 275 with coordinates deposited in the Protein Data Bank (PDB) can be directly rotated, zoomed, and viewed. Top left: Amphibian magainin II; Top right: bovine lactoferricin; Bottom left: plant PsD1; Bottom right: bovine indolicidin.
This original database consists of a pipeline of search functions for innate immune peptides. You can search for peptide information using APD ID, peptide name, amino acid sequence, peptide motif, chemical modification, length, charge, hydrophobic content, PDB ID, 3D structure, methods for structural determination, peptide source organism, peptide family name, life domain/kingdom (bacteria, archaea, protists, fungi, plants, animals), biological activity (see the links above), synergistic effects, target microbes, molecular targets, mechanism of action, contributing authors, and year of publication.
. Wang, G., Li, X. and Wang, Z. (2016) APD3: the antimicrobial peptide database as a tool for research and education.
Nucleic Acids Research 44, D1087-D1093. Paper PDF
. Wang, G., Li, X. and Wang, Z. (2009) APD2: the updated antimicrobial peptide database and its application in peptide design.
Nucleic Acids Research 37, D933-D937. Paper PDF
. Wang, Z. and Wang, G. (2004) APD: the antimicrobial peptide database.
Nucleic Acids Research 32, D590-D592. Paper PDF