The Antimicrobial Peptide Database (APD) contains 2439 antimicrobial peptides (242 bacteriocins from bacteria, 2 from archaea, and 2154 from eukaryotes [7 from protists, 12 from fungi, 311 from plants, and 1824 from animals]) with the following activity:
A comprehensive AMP database resource manually curated based on a set of data-collection criteria (see About).
There are 106 host defense peptides from humans, 946 active peptides from amphibians, 79 from fish, 14 from reptiles, 36 from birds, 230 from insects, 33 from spiders, 33 from crustaceans, and more.
Of the 323 unique 3D structures annotated in the APD, 213 with coordinates deposited in the PDB can be rotated, zoomed, and viewed.Top left: Amphibian magainin II;Top right: bovine lactoferricin;Bottom left: plant PsD1;Bottom right: bovine indolicidin.
This database consists of a pipeline of search functions. You can search for peptide information using APD ID, peptide name, amino acid sequence, peptide motif, chemical modification, length, charge, hydrophobic content, PDB ID, 3D structure, methods for structural determination, peptide source organism, peptide family name, life kingdoms/domains (bacteria, archaea, protists, fungi, plants, animals), biological activity (see the links above), synergistic effects, target microbes, molecular targets, mechanism of action, contributing authors, and year of publication.
In addition, you can access the APD Peptide Calculator here.
CITE: 1. Wang, G., Li, X. and Wang, Z. (2009) APD2: the updated antimicrobial peptide database and its application in peptide design.
Nucleic Acids Research 37, D933-D937. Paper PDF
2. Wang, Z. and Wang, G. (2004) APD: the antimicrobial peptide database.
Nucleic Acids Research 32, D590-D592.] Paper PDF