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The Antimicrobial Peptide Database (APD) contains 2707 antimicrobial peptides from six kingdoms (269 bacteriocins from bacteria, 4 from archaea, 8 from protists, 13 from fungi, 333 from plants, and 2034 from animals) with the following activity:
Antibacterial Peptides (Antibiofilms)
Antiviral Peptides (Anti-HIV)
Antifungal Peptides
Antiparasitic Peptides (Antimalaria)
Anticancer Peptides
Anti-protist Peptides
Insecticidal Peptides
Spermicidal Peptides
Chemotactic peptides
wound healing
Antioxidant peptides
Protease inhibitors
This comprehensive AMP database resource is manually curated based on a set of data-collection criteria (see About).
There are 113 human host defense peptides, 1011 active peptides from amphibians, 99 fish peptides, 22 reptile peptides, 38 from birds, 462 from arthropods, 136 from chelicerata, 44 from crustaceans, 6 from myriapods, 272 from insects, 42 from spiders, 65 from scorpions, 34 from molluscs; and more. A Universal Peptide Nomenclature; A Unified Peptide Classification

Of the 369 unique 3D structures annotated in the APD, 263 with coordinates deposited in the Protein Data Bank (PDB) can be directly rotated, zoomed, and viewed. Top left: Amphibian magainin II; Top right: bovine lactoferricin; Bottom left: plant PsD1; Bottom right: bovine indolicidin. A unified Peptide 3D Structure Classification

This original database consists of a pipeline of search functions. You can search for peptide information using APD ID, peptide name, amino acid sequence, peptide motif, chemical modification, length, charge, hydrophobic content, PDB ID, 3D structure, methods for structural determination, peptide source organism, peptide family name, life domain/kingdom (bacteria, archaea, protists, fungi, plants, animals), biological activity (see the links above), synergistic effects, target microbes, molecular targets, mechanism of action, contributing authors, and year of publication.
Antimicrobial Peptides in 2014

Wang, G., Li, X. and Wang, Z. (2016) APD3: the antimicrobial peptide database as a tool for research and education. Nucleic Acids Research 44, D1087-D1093. Paper PDF
[2]. Wang, G., Li, X. and Wang, Z. (2009) APD2: the updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Research 37, D933-D937. Paper PDF
[3]. Wang, Z. and Wang, G. (2004) APD: the antimicrobial peptide database. Nucleic Acids Research 32, D590-D592. Paper PDF

Last updated: May 27, 2016 | Copyright 2003-2016 Dept of Pathology & Microbiology, UNMC, All Rights Reserved