Antimicrobial Peptide AP02846

     
 

APD ID:

AP02846

 
 

Name/Class:

Urumin (frog, amphibians, animals; ; 1S=S, XXU, UCSS1a)

 
 

Source:

Hydrophylax bahuvistara, India, Asia

 
 

Sequence:

IPLRGAFINGRWDSQCHRFSNGAIACA

 
 

Length:

27

 
 

Net charge:

2

 
 

Hydrophobic residue%:

48%

 
 

Boman Index:

1.59 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Antiviral,

 
 

Crucial residues:

 
 

Additional info:

APD analysis reveals that the sequence of Urumin is unique and ONLY shows 36.7% similarity to bacterial Siamycin II, known also to be antiviral. C2: molecular formula: C129H201N40O35S2; Mol Wt 2961.39; GRAVY= -0.033; Wimley-White whole-residue hydrophobicity of the peptide: 0.59 kcal/mol. It is uncommon that an amphibian peptide is specifically active against human H1 Hemagglutinin-Bearing Influenza A Viruses (IAV H1N1). The IC50 of urumin was 3.8 uM. For urumin, the toxic dose (TD50) was 2,450 uM (Figure 1C), leading to a TI = TD50/IC50 644.7, indicative of a favorable therapeutic profile. No activity against other viruses tested. The peptide synthesized in D-amino acids is inactive, in agreement with a non-membrane H1 Hemagglutinin target Comment on this work. AMP News. Updated 12/2017. 5/2019

 
       
 

Title:

An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin-Bearing Influenza Viruses

 
 

Author:

Holthausen DJ, Lee SH, Kumar VT, Bouvier NM, Krammer F, Ellebedy AH, Wrammert J, Lowen AC, George S, Pillai MR, Jacob J. 2017

 
 

Reference:

Immunity. 2017 Apr 18;46(4):587-595. PubMed

 
       

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