Antimicrobial Peptide AP02649

     
 

APD ID:

AP02649

 
 

Name/Class:

cOB1 (pheromone, Gram-positive commensal bacteria, prokaryotes; UCLL1a)

 
 

Source:

Enterococcus faecalis

 
 

Sequence:

VAVLVLGA

 
 

Length:

8

 
 

Net charge:

0

 
 

Hydrophobic residue%:

87%

 
 

Boman Index:

-3.31 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Anti-Gram+,

 
 

Crucial residues:

 
 

Additional info:

APD analysis reveals that the sequence of this peptide most resembles (44.4% similarity) Baceridin. Originally identified as a sex pheromone (Nakayama J et al., 1995, Isolation and Structure of the Enterococcus faecalis Sex Pheromone, cOB1, That Induces Conjugal Transfer of the Hemolysin/Bacteriocin Plasmids, pOB1 and pYI1 (plasmid-encoded), Japan Society of Biosci. Biotech. and Agrochem, Tokyo, pp. 703-705), cOB1 of Commensal E. faecalis can restrict the growth of multidrug-resistant E. faecalis V583 in the gut at an extremely low concentration (MIC 22 pg/mL). The killing mechanism is under investigation but apparently differs from the classic AMPs that target membranes. This study indicates the importance of maintaining the commensal population as a means of preventing infection. 4/2016.

 
       
 

Title:

Pheromone killing of multidrug-resistant Enterococcus faecalis V583 by native commensal strains

 
 

Author:

Gilmore MS, Rauch M, Ramsey MM, Himes PR, Varahan S, Manson JM, Lebreton F, Hancock LE.2015

 
 

Reference:

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7273-8. PubMed

 
       

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