Antimicrobial Peptide AP01794“>017943182.05 %92.21 %AVP
     
 

APD ID:

AP01794

 
 

Name/Class:

Temporin-1CEa (UCLL1c; frog, amphibians, animals; XXA)

 
 

Source:

Asia, Chinese brown frog, Rana chensinensis

 
 

Sequence:

FVDLKKIANIINSIF

 
 

Length:

15

 
 

Net charge:

2

 
 

Hydrophobic residue%:

60%

 
 

Boman Index:

0 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

CD

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Anti-Gram+, Anticancer

 
 

Crucial residues:

 
 

Additional info:

Shang D et al (2009) reported previously "Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis" (Zoolog Sci. 2009 Mar;26(3):220-6). Temporin-1CEa adopted a well-defined helical structure in 50% TFE/water solution. Active against plant pathogens Gram- X. arboricola pv. pruni and X. axonopodis pv. vesicatoria (MIC 3.1-6.2 uM) (Cam C et al. 2018). It appears to kill breast cancer cells by membrane disruption Wang C et al., 2013. In particular, human A375 melanoma cells express 50-fold more phosphatidylserine (PS) expressed on cancer cell surface serves as a target for temporin-1CEa. Our results indicate PS than noncancerous HaCaT cells. Anticancer activity is reduced by annexin V, which binds PS. APD update 7/14/12; 4/12/13; 12/2015; 5/2016; 12/2018 GW.

 
       
 

Title:

Antitumor effects and cell selectivity of temporin-1CEa, an antimicrobial peptide from the skin secretions of the Chinese brown frog (Rana chensinensis)

 
 

Author:

Wang C, Li HB, Li S, Tian LL, Shang DJ.2011

 
 

Reference:

Biochimie. 2012 Feb;94(2):434-41. PubMed.

 
       

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