Antimicrobial Peptide AP01532

     
 

APD ID:

AP01532

 
 

Name/Class:

Lucifensin (Lucilia sericata Meigen defensin, UCSS1a; insects, arthropods, invertebrates, animals; 3S=S; BBW)

 
 

Source:

gut, salivary glands, fat body, haemolymph; blowfly; maggots; Lucilia sericata

 
 

Sequence:

ATCDLLSGTGVKHSACAAHCLLRGNRGGYCNGRAICVCRN

 
 

Length:

40

 
 

Net charge:

4

 
 

Hydrophobic residue%:

45%

 
 

Boman Index:

1.5 kcal/mol

 
 

3D Structure:

Combine Helix and Beta structure

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 2LLD   Go to PDB

 
 

Activity:

Anti-Gram+, Wound healing,

 
 

Crucial residues:

 
 

Additional info:

First isolated from the gut of L sericata larvae. Also detected in salivary glands, fat body and haemolymph (provided by the authors). Active against M. luteus. Lucifensin adopts a characteristic insect defensin structure that includes an alpha helix (residues 13-23) and a pair of beta-strands (residues 28-31 and 34-38) (Nygaard et al. 2012 J. Biomol. NMR 52: 277-282). You can rotate, zoom, and view the 3D structure here in the PDB. Updated 6/26/13; 2/2014.

 
       
 

Title:

Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata

 
 

Author:

Cerovsky V, Zdárek J, Fucík V, Monincová L, Voburka Z, Bém R.2010

 
 

Reference:

Cell Mol Life Sci. 2010 Feb;67(3):455-66. Pub-Med.

 
       

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