Antimicrobial Peptide AP01339“>013392658.67 %100.0 %AVP
     
 

APD ID:

AP01339

 
 

Name/Class:

BHP (Hb 33-61; Bovine hemoglobin peptide, ruminant, mammals, animals; UCLL1)

 
 

Source:

the tick Boophilus microplus

 
 

Sequence:

FLSFPTTKTYFPHFDLSHGSAQVKGHGAK

 
 

Length:

29

 
 

Net charge:

2

 
 

Hydrophobic residue%:

31%

 
 

Boman Index:

1.05 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Anti-Gram+, Antifungal,

 
 

Crucial residues:

 
 

Additional info:

BHP corresponds to residues 33-61 of bovine hemoglobin and was generated in the tick gut for defense. Note that whole hemoglobin of the cow is not antimicrobial but is used as a source for antimicrobial peptide production. Active against Gram+ M. luteus A270 (MIC 5 uM), S. epidermidis (MIC 21 uM), and fungi C. albicans (MIC 5 uM), S. cerevisiae (MIC 11), and A. nidulans (MIC 1.3 uM). Updated 2/2019.

 
       
 

Title:

Antibacterial activity of a pepsin-derived bovine hemoglobin fragment.

 
 

Author:

Fogaça AC, da Silva PI Jr, Miranda MT, Bianchi AG, Miranda A, Ribolla PE, Daffre S1999

 
 

Reference:

J Biol Chem. 1999 Sep 3;274(36):25330-4. Pub-Med.

 
       

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