Antimicrobial Peptide AP01291

     
 

APD ID:

AP01291

 
 

Name/Class:

Odorranain-B1 (OdB1; ORB; Ranacyclin B1; UCLL1; frog, amphibians, animals; Derivatives: ORBK)

 
 

Source:

Odorrana grahami, Asia

 
 

Sequence:

AALKGCWTKSIPPKPCFGKR

 
 

Length:

20

 
 

Net charge:

5

 
 

Hydrophobic residue%:

40%

 
 

Boman Index:

0.99 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

CD

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

anti-Gram+ & Gram-, antifungal, Enzyme inhibitor,

 
 

Crucial residues:

 
 

Additional info:

The peptide has been reported in different articles in different names. In addition to antimicrobial activity, the peptide also inhibits trypsin due to the disulfide-bonded trypsin inhibitory loop in the sequence (enzyme inhibitor) (Li J et al 2007 FASEB J 21: 2466-73). In this proteomic paper, 372 cDNA sequences of antimicrobial peptides were found in a single frog. Among them, 107 are new peptides. Approximately 40 peptides were synthesized and tested. Only 24 peptides with antimicrobial acitivities (APD entries 1291-1314) were registered into this database. OBR1 is active against E. coli ATCC25922 (MIC 5.83 ug/ml), S. aureus ATCC2592 (MIC 5.83 ug/ml), B. dysenteria (1.84 ug/ml), and C. albicans ATCC2002 (2.4 ug/ml). Derivatives: ORB-C (sequence CWTKSIPPKPC, disulfide bridged) has improved trypsin inhibition ability but lost its antimicrobial activity. ORB1 is N-terminal AA truncated form.

 
       
 

Title:

Anti-infection peptidomics of amphibian skin

 
 

Author:

Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J.2007

 
 

Reference:

Mol Cell Proteomics. 2007 May;6(5):882-94. Pub-Med.

 
       

Close this window