Antimicrobial Peptide AP01206

     
 

APD ID:

AP01206

 
 

Name/Class:

Mersacidin (type-B lantibiotics, type 2, class 1 bacteriocin, Gram-positive bacteria, prokaryotes; UCSS1b; XXT; BBW)

 
 

Source:

Bacillus sp. strain HIL Y-85 54728

 
 

Sequence:

CTFTLPGGGGVCTLTSECIC

 
 

Length:

20

 
 

Net charge:

-1

 
 

Hydrophobic residue%:

45%

 
 

Boman Index:

-0.5 kcal/mol

 
 

3D Structure:

nonhelixbeta

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 1MQZ   Go to PDB

 
 

Activity:

Anti-Gram+, Anti-MRSA,

 
 

Crucial residues:

 
 

Additional info:

Active against S. aureus 209P (MIC 1.56 ug/ml), S. aureus R85 (MIC 0.78 ug/ml), S. aureus 20424 (MIC 3.12 ug/ml), S. aureus 503 (MIC 1.56 ug/ml), S. epidermidis 823 (MIC 6.25 ug/ml), S. faecalis 21777 (MIC 50 ug/ml), S. pneumoniae A77 (MIC 3.12 ug/ml), B. subtilis ATCC6633 (MIC 0.78 ug/ml) and M. luteus ATCC 9341 (MIC 0.195 ug/ml). The smallest lantibiotic known to date. There are 9 post-translational modifications leading to four ring structures, residues 1-2,4-12, 13-18, and 15-20. Residues 2,4,13, and 15 are Abu. The ring structure confers chemical stability and proteolysis resistance of the peptide. You can rotate, zoom, and view the 3D structure here in the PDB. Active against MRSA, VRE, C. difficile. MOA: it targets the sugar phosphate head group of the peptidoglycan precursor lipid II and inhibits the transglycosylation of peptidoglycan biosynthesis of the cell wall. Updated 2/2014;4/2016.4/2019 CW

 
       
 

Title:

Mersacidin, a new antibiotic from Bacillus. Fermentation, isolation, purification and chemical characterization.

 
 

Author:

Chatterjee S, Chatterjee S, Lad SJ, Phansalkar MS, Rupp RH, Ganguli BN, Fehlhaber HW, Kogler H.1992

 
 

Reference:

J Antibiot (Tokyo). 1992 Jun;45(6):832-8

 
       

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