Antimicrobial Peptide AP00857

     
 

APD ID:

AP00857

 
 

Name/Class:

Catestatin (human CHGA(352-372), SL21, human Cst; a neuropeptide; primates, mammals, animals)

 
 

Source:

Homo sapiens

 
 

Sequence:

SSMKLSFRARAYGFRGPGPQL

 
 

Length:

21

 
 

Net charge:

4

 
 

Hydrophobic residue%:

33%

 
 

Boman Index:

1.98 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

anti-Gram+ & Gram-, antifungal, Chemotactic, Antioxidant,

 
 

Crucial residues:

 
 

Additional info:

Active against S. aureus and P. aeruginosa. This sequence is highly conserved across species. There are three single nucleotide polymorphisms: G364S, P370L, and R374Q. The G364S and R374Q mutants are inactive while the P370L mutant is more active than the WT. A recent study (Radek et al. Gallo, RL 2008. J Invest Dermatol 128:1525-34) established that this peptide is upregulated upon injury of skin and is part of cutaneous immune systems. It can induce mast cell migration, degranulation and production of cytokines and chemokines (Aung G et al 2011 Immunology 132:527-39). The peptide is also antioxidant, thereby preventing free radical-induced DNA damage (Mohseni S et al., 2014). Updated 9/11; 4/2014 GW.

 
       
 

Title:

New antimicrobial activity for the catecholamine release-inhibitory peptide from chromogranin A

 
 

Author:

Briolat J et al Metz-Boutigue MH2005

 
 

Reference:

Cell Mol Life Sci 2005; 62: 377-385

 
       

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