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APD ID: |
AP00764 |
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Name/Class: |
Dermaseptin-S9 (DRS-S9, Dermaseptin S9, DRS S9, UCLL1; frog, amphibians, animals; ZZH) |
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Source: |
South America, hylid frog, Phyllomedusa sauvagei |
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Sequence: |
GLRSKIWLWVLLMIWQESNKFKKM |
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Length: |
24 |
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Net charge: |
4 |
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Hydrophobic residue%: |
54% |
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Boman Index: |
0.57 kcal/mol |
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3D Structure: |
Helix |
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Method: |
NMR |
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SwissProt ID: |
Reference ID:
Ref |
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Activity: |
anti-Gram+ & Gram-, antiviral, anti-HIV, Chemotactic, |
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Crucial residues: |
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Additional info: |
Drs S9 can induce the migration of immune cells such as neutrophils, T lymphocytes and monocytes. Residues 6-21 are helical in TFE. Also, an arginine mutant of this peptide is HIV active (Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346). |
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Title: |
Dermaseptin S9, an alpha-helical antimicrobial peptide with a hydrophobic core and cationic termini |
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Author: |
Lequin O et al Amiche M2006 |
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Reference: |
Biochemistry 2006; 45: 468-480 |
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