Antimicrobial Peptide AP00764

APD ID:

AP00764

Name/Class:

Dermaseptin-S9 (DRS-S9, Dermaseptin S9, DRS S9, UCLL1; frog, amphibians, animals; ZZH)

Source:

South America, hylid frog, Phyllomedusa sauvagei

Sequence:

GLRSKIWLWVLLMIWQESNKFKKM

Length:

24

Net charge:

4

Hydrophobic residue%:

54%

Boman Index:

0.57 kcal/mol

3D Structure:

Helix

Method:

NMR

SwissProt ID:

Reference ID: Ref  

Activity:

anti-Gram+ & Gram-, antiviral, anti-HIV, Chemotactic,

Crucial residues:

Additional info:

Drs S9 can induce the migration of immune cells such as neutrophils, T lymphocytes and monocytes. Residues 6-21 are helical in TFE. Also, an arginine mutant of this peptide is HIV active (Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346).

Title:

Dermaseptin S9, an alpha-helical antimicrobial peptide with a hydrophobic core and cationic termini

Author:

Lequin O et al Amiche M2006

Reference:

Biochemistry 2006; 45: 468-480