Antimicrobial Peptide AP00674

     
 

APD ID:

AP00674

 
 

Name/Class:

Planosporicin (Lantibiotic 97518; type 1, class 1 bacteriocin, Gram-positive bacteria, prokaryotes; XXT5; XXW2; UCSS1b; revisited)

 
 

Source:

Planomonospora alba

 
 

Sequence:

ITSVSWCTPGCTSEGGGSGCSHCC

 
 

Length:

24

 
 

Net charge:

-1

 
 

Hydrophobic residue%:

33%

 
 

Boman Index:

0.57 kcal/mol

 
 

3D Structure:

Unknown

 
 

Method:

NMR

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Anti-Gram+ & Gram-, Anti-MRSA,

 
 

Crucial residues:

 
 

Additional info:

The primary structure, as well as the mode of intrabonds, of the peptide has been revised based on a combined analytical techniques (Maffioli SI et al 2009). The updated sequence before post translation is diaplayed. Residues T2 and S5 are dehydrated. Lanthionines occur between S3-C7, S13-C20, S18-C23, and S21-C24. One methyllanthionine is proposed between T8 and C11. In addition, the carboxylic acids of E14 and the C-terminus are benzylamidated. The peptide is not active against E.coli and C.albicans, but is active against Gram-negative pathogenic bacterium M. catarrhalis (MIC 1 ug/ml). It inhibits cell wall synthesis of Gram-positive bacteria, including MRSA. 3D structure has been determined by NMR (Vasile F et al., 2012). Updated 5/2014.

 
       
 

Title:

A novel lantibiotic acting on bacterial cell wall synthesis produced by the uncommon actinomycete Planomonospora sp.

 
 

Author:

Castiglione F, Cavaletti L, Losi D, Lazzarini A, Carrano L, Feroggio M, Ciciliato I, Corti E, Candiani G, Marinelli F, Selva E.2007

 
 

Reference:

Biochemistry. 2007 May 22;46(20):5884-95

 
       

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