Antimicrobial Peptide AP00602“>006022885.39 %91.54 %AVP
     
 

APD ID:

AP00602

 
 

Name/Class:

Brevinin-1DYb (Amurin-2; frog, amphibians, animals; XXU; 1S=S, UCSS1a)

 
 

Source:

Rana dybowskii, or Rana amurensis, Asia

 
 

Sequence:

FLSLALAALPKLFCLIFKKC

 
 

Length:

20

 
 

Net charge:

3

 
 

Hydrophobic residue%:

75%

 
 

Boman Index:

-1.56 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

CD

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal, Anti-MRSA, Hemolytic, Anticancer

 
 

Crucial residues:

 
 

Additional info:

It is also identified in another species in 2018 (Zhang et al. BBRC2018). Found in multiple species. Amurin-2 is active against S. aureus or MRSA (MIC 32 uM), C. albicans (MIC 32 uM). It is hemolytic HC 50 4.7 uM. Helical in 50% TFE. Updated 12/2018.

 
       
 

Title:

Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii

 
 

Author:

Conlon JM et al. Iwamuro S2007

 
 

Reference:

Toxicon 2007; 50: 746-756. PubMed.

 
       

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