Antimicrobial Peptide AP00601

     
 

APD ID:

AP00601

 
 

Name/Class:

Brevinin-1DYa (Amurin-2c; frog, amphibians, animals; XXU; 1S=S, UCSS1a; Amurin-2a)

 
 

Source:

Rana dybowskii, or Rana amurensis, Asia

 
 

Sequence:

FLSLALAALPKFLCLVFKKC

 
 

Length:

20

 
 

Net charge:

3

 
 

Hydrophobic residue%:

75%

 
 

Boman Index:

-1.52 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

CD

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal, candidacidal, Anti-MRSA, Hemolytic, Anticancer

 
 

Crucial residues:

 
 

Additional info:

Active against E. coli and S. aureus (MIC < 15 uM) and hemolytic. It is also identified in another species in 2018 (Zhang et al. BBRC2018). Found in multiple species. Active against S. aureus or MRSA (MIC 32 uM), C. albicans (MIC 32 uM). It is hemolytic HC 50 =17 uM. This peptide also inhibits cancer cells H157, PC-3, U251MG, MB435S, and MCF-7. Toxic to HMEC-1 (IC50 at 35 uM). Helical in 50% TFE. Amurin-2a is very very weak in antimicrobial (MIC >>100 uM). Updated 12/2018; 5/2020

 
       
 

Title:

Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii

 
 

Author:

Conlon JM et al. Iwamuro S2007

 
 

Reference:

Toxicon 2007; 50: 746-756. PubMed.

 
       

Close this window