Antimicrobial Peptide AP00557

     
 

APD ID:

AP00557

 
 

Name/Class:

Chicken CATH-1 ( chicken cathelicidin 1, Fowlicidin-1; chCATH-1; birds, animals; BBL)

 
 

Source:

Gallus galllus

 
 

Sequence:

RVKRVWPLVIRTVIAGYNLYRAIKKK

 
 

Length:

26

 
 

Net charge:

8

 
 

Hydrophobic residue%:

46%

 
 

Boman Index:

1.68 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 2AMN   Go to PDB

 
 

Activity:

Anti-Gram+ & Gram-, Anti-MRSA, Anti-inflammatory, anti-sepsis,

 
 

Crucial residues:

 
 

Additional info:

Active against E. coli O157:H7, S. typhimurium, K. pneumoniae, P. aeruginosa (MIC 0.4-3.1 uM), L. monocytogenes, S. aureus (MRSA) (MIC 0.40-0.8 uM). You can rotate, zoom, and view the 3D structure in 50% TFEhere in the PDB. Fowlicidin(6-26)-NH2 retained antibacterial activity for 2h in serum. Animal model:mouse: It increased mice survival by 50% from a lethal dose of MRSA. This truncated peptide also reduced TNF-alpha and NO production in macrophage by 77% and 96%, respectively (i.e., anti-inflammatory). Thus, this fragment may have therapeutic potential for drug-resistant bacterial infection as well as sepsis (Bommineni et al 2010 Peptides 31: 1225). 11/2017; 6/2018.

 
       
 

Title:

Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity

 
 

Author:

Xiao Y, Cai Y, Bommineni YR, Fernando SC, Prakash O, Gilliland SE, Zhang G2006

 
 

Reference:

J Biol Chem. 2006 Feb 3;281(5):2858-67.

 
       

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