Antimicrobial Peptide AP00546

     
 

APD ID:

AP00546

 
 

Name/Class:

Phylloseptin-H1 (PLS-H1, Phylloseptin-1, PS-1, XXA, UCLL1c; frog, amphibians, animals; ZZP)

 
 

Source:

Brazilian tree frog, Phylllomedusa hypochondrialis, South America

 
 

Sequence:

FLSLIPHAINAVSAIAKHN

 
 

Length:

19

 
 

Net charge:

2

 
 

Hydrophobic residue%:

57%

 
 

Boman Index:

-0.2 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 2jq0   Go to PDB

 
 

Activity:

Anti-Gram+, Antimalarial,

 
 

Crucial residues:

 
 

Additional info:

Active against S. aureus ATCC (MIC 7.9 uM), E. faecalis ATCC (MIC 4.0 uM), E. coli ATCC (MIC 7.9 uM), and P. aeruginosa (MIC 3-4 uM). Also active against P. falciparum. You can rotate, zoom, and view the 3D structure in 60% TFEhere in the PDB. Updated 2/2014; 6/2019.

 
       
 

Title:

Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.

 
 

Author:

Leite JR, Silva LP, Rodrigues MI, Prates MV, Brand GD, Lacava BM, Azevedo RB, Bocca AL, Albuquerque S, Bloch C Jr.2005

 
 

Reference:

Peptides 2005; 26: 565-573. PubMed.

 
       

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