Antimicrobial Peptide AP00522

     
 

APD ID:

AP00522

 
 

Name/Class:

Agelaia-MP (Agelaia-MP-I; insects, arthropods, invertebrates, animals; XXA)

 
 

Source:

social wasp, Agelaia pallipes pallipes

 
 

Sequence:

INWLKLGKAIIDAL

 
 

Length:

14

 
 

Net charge:

2

 
 

Hydrophobic residue%:

64%

 
 

Boman Index:

-0.71 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Anti-Gram+ & Gram-, Hemolytic, Antibiofilm,

 
 

Additional info:

Poorly active against S. aureus (MIC 120 uM) (ref. see AP1640), A. baumannii (3.1-6.2 uM). Agelaia-MPI showed adhesion inhibition for isolates AB 02 at a concentration of 25 M while isolates AB 53 and AB 72 were inhibited at a concentration of 6.25 and 12.5 M, respectively (das Neves RC et al. 2019). Agelaia-MP was characterized as a hemolytic mast cell degranulator toxin, presenting a poor antimicrobial action and no chemotaxis for PMNL. This peptide promotes insulin secretion in mice pancreatic islets (Baptista-Saidemberg et al., 2012), thereby of interest for type 2 diabetes (T2D). The original Dhvar5 has been replaced 9/30/10; Jan2017; 5/2017; 4/2019.

 
       
 

Title:

Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes

 
 

Author:

Mendes MA, de Souza BM, Marques MR, Palma MS.2004

 
 

Reference:

Toxicon. 2004 Jul;44(1):67-74. Pub-Med.

 
       

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