Antimicrobial Peptide AP00521

     
 

APD ID:

AP00521

 
 

Name/Class:

Protonectin (insects, arthropods, invertebrates, animals; XXA)

 
 

Source:

venom, social wasp, Protonectarina sylveirae; Agelaia pallipes pallipes; Parachartergus fraternus

 
 

Sequence:

ILGTILGLLKGL

 
 

Length:

12

 
 

Net charge:

2

 
 

Hydrophobic residue%:

58%

 
 

Boman Index:

-2.42 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

CD

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Anti-Gram+ & Gram-, Chemotactic,

 
 

Crucial residues:

Helical conformation is critical for peptide activity (Wang K et al, 2013.).

 
 

Additional info:

Active against E. coli (MIC 20 uM), P. aeruginosa (MIC 1 uM), and S. aureus (MIC 10 uM) (ref. see AP1640). Protonectin is a non-hemolytic chemotactic peptide for polymorphonucleated leukocytes (PMNL), presenting some mast cell degranulating activity and potent antimicrobial action both against Gram-positive and Gram-negative bacteria. This peptide is found in multiple species. The original Dhvar4 has been replaced 9/30/10. Updated 7/2013; 3/2019.

 
       
 

Title:

Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes

 
 

Author:

Mendes MA, de Souza BM, Marques MR, Palma MS.2004

 
 

Reference:

Toxicon. 2004 Jul;44(1):67-74. Pub-Med.

 
       

Close this window