Antimicrobial Peptide AP00519

     
 

APD ID:

AP00519

 
 

Name/Class:

Ib-AMP4 (Ib antimicrobial peptide 4, UCSS1a; 2S=S, plants, XXQ, SeqAR)

 
 

Source:

seeds, Impatiens balsamina (Ib)

 
 

Sequence:

QWGRRCCGWGPGRRYCRRWC

 
 

Length:

20

 
 

Net charge:

6

 
 

Hydrophobic residue%:

35%

 
 

Boman Index:

3.96 kcal/mol

 
 

3D Structure:

Bridge

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Anti-Gram+, Antifungal, Anti-MRSA,

 
 

Additional info:

The N-terminal glutamine is believed to be cyclized (i.e., pyroglutamate, XXQ). It contains two disulfide bonds (6-16 and 7-20). A recombinant form is active against clinical multiresistant isolates including MRSA (S. aureus) and extended spectrum -lactamases-producing E. coli ( Fan X et al., 2013). Activity and sequence relationship was investigated (Peptides. 2005 Jul;26(7):1113-9). Updated 5/30/2013.

 
       
 

Title:

A Novel Family of Small Cysteine-rich Antimicrobial Peptides from Seed of Impatiens balsamina Is Derived from a Single Precursor Protein

 
 

Author:

Tailor RH, Acland DP, Attenborough S, Cammue BP, Evans IJ, Osborn RW, Ray JA, Rees SB, Broekaert WF.1997

 
 

Reference:

J. Biol. Chem., Sep 1997; 272: 24480 - 24487

 
       

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