Antimicrobial Peptide AP00517

     
 

APD ID:

AP00517

 
 

Name/Class:

Lycotoxin II (spiders, arachnids, Chelicerata, arthropods, invertebrates, animals; UCLL1a)

 
 

Source:

Wolf Spider Lycosa carolinensis

 
 

Sequence:

KIKWFKTMKSIAKFIAKEQMKKHLGGE

 
 

Length:

27

 
 

Net charge:

6

 
 

Hydrophobic residue%:

40%

 
 

Boman Index:

1.33 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

anti-Gram+ & Gram-, Enzyme inhibitor,

 
 

Additional info:

The predicted secondary structures of the lycotoxins display amphipathic alpha-helix. Active against E. ocli (MIC <10-40 uM), B. thuringiensis subsp. israelensis (MIC 10-60 uM) and weakly active against C. glabrata ATCC 2001. This peptide also inhibits Escherichia coli ATP synthase (Azim et al., 2016). Updated 5/2015; 3/2016.

 
       
 

Title:

Lycotoxins, Antimicrobial Peptides from Venom of the Wolf Spider Lycosa carolinensis.

 
 

Author:

Yan L, Adams ME1998

 
 

Reference:

J Biol Chem. 1998 Jan 23;273(4):2059-66. PubMed.

 
       

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