Antimicrobial Peptide AP00504“>005042565.80 %96.38 %AVP
     
 

APD ID:

AP00504

 
 

Name/Class:

human MUC7 20-Mer ( primates, mammals, animals)

 
 

Source:

Homo sapiens

 
 

Sequence:

LAHQKPFIRKSYKCLHKRCR

 
 

Length:

20

 
 

Net charge:

7

 
 

Hydrophobic residue%:

35%

 
 

Boman Index:

3.16 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal,

 
 

Additional info:

Derived from the C-terminal region (residues 32-51, where 7 out 8 basic residues are located) of MUC7 domain 1. Activity was initially reported in a previous study (Smith CJ and Bobek LA 2001 J Dent Res 80:601). Active against bacteria A. actinomycetemcomitans, E. coli, P. aeruginosa, S. mutans (cariogenic bacteria), P. gingivalis, and S. gordonii (MIC 1-4.4 uM), fungi C. albicans, C. glabrata, C. krusei, and C. neoformans CN2, and S. cerevisiae (MIC 2.4-5.8 uM) (including resistant forms of C. albicans, C. glabrata, and C, neoformans) (MIC 2.4-12.3 uM). The secondary structure prediction showed that MUC7 20-mer adopts an amphiphilic helix. The peptide is still active after removing the first eight residues (MUC7 12-mer). In saliva (proteases and ionic strength), the D-form of MUC7-12mer is more active than the L-form, although they showed similar activity in phosphate buffer (PBS) (D=L). Updated 12/2014.

 
       
 

Title:

MUC7 20-Mer: Investigation of Antimicrobial Activity, Secondary Structure, and Possible Mechanism of Antifungal Action.

 
 

Author:

Bobek LA, Situ H2001

 
 

Reference:

Antimicrob Agents Chemother 2003 Feb;47(2):643-52. PubMed

 
       

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