Antimicrobial Peptide AP00498

     
 

APD ID:

AP00498

 
 

Name/Class:

rCRAMP (rat cathelin-related antimicrobial peptide, cathelicidin; animals)

 
 

Source:

M2 macrophage, islet beta cells, delta cells; Norway rat, Rattus norvegicus

 
 

Sequence:

GLVRKGGEKFGEKLRKIGQKIKEFFQKLALEIEQ

 
 

Length:

34

 
 

Net charge:

4

 
 

Hydrophobic residue%:

35%

 
 

Boman Index:

1.92 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

Reference ID: Ref  

 
 

Activity:

Anti-Gram+ & Gram-, Anti-MRSA,

 
 

Additional info:

Activity against E. coli DH5a, E. coli ML-35p, P. aeruginosa PAO1, P. aeruginosaMR3007, MRSA ATCC 33591, S. aureus 93918 (MIC 0.25-2 uM). The MIC increased from 2.4 to 18 uM in the case of MRSA with an increase in NaCl concentration to 100 mM. Updated Jan2017.

 
       
 

Title:

Bactericidal activity of mammalian cathelicidin-derived peptides.

 
 

Author:

Travis SM, Anderson NN, Forsyth WR, Espiritu C, Conway BD, Greenberg EP, McCray PB Jr, Lehrer RI, Welsh MJ, Tack BF.2000

 
 

Reference:

Infect Immun. 2000 May;68(5):2748-55

 
       

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