Antimicrobial Peptide AP00396

     
 

APD ID:

AP00396

 
 

Name/Class:

PR-39 (PR39, a proline-arginine-rich peptide with 39 residues, XXA, cathelicidin, pigs, mammals; animals; Pro-rich; Arg-rich; BBN)

 
 

Source:

Pig neutrophils; , Sus scrofa

 
 

Sequence:

RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP

 
 

Length:

39

 
 

Net charge:

11

 
 

Hydrophobic residue%:

20%

 
 

Boman Index:

3.04 kcal/mol

 
 

3D Structure:

Rich

 
 

SwissProt ID:

SwissProt ID: P80054  Go to SwissProt

 
 

Activity:

anti-Gram+ & Gram-, wound healing, Cancer cells

 
 

Additional info:

Active against E. coli K12, B. megoturium (lethal conc 0.3 uM), S. typhimurium, Strep. pyogmes, A. calccouceticus (lethal conc 1-3 uM), and B. subtilis (15 uM). MOA: it probably binds to DNA (Boman HG et al. 1993 Infect Immun 61: 2978-84). In vitro, PR-39 retarded DNA migration in the 0.8% agarose gel (Baumann A et al., 2014). Updated 8/2014; 8/2017.

 
       
 

Title:

Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides

 
 

Author:

Agerberth B, Lee JY, Bergman T, Carlquist M, Boman HG, Mutt V, Jörnvall H.1991

 
 

Reference:

Eur J Biochem. 1991 Dec 18;202(3):849-54. PubMed.

 
       

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