Antimicrobial Peptide AP00367

     
 

APD ID:

AP00367

 
 

Name/Class:

BMAP-28 (BMAP28, bovine myeloid antimicrobial peptide 28; bovine cathelicidin-5, cattle, ruminant, mammals, animals; BBMm;ZZP; UCLL1; Derivatives: mBMAP-28

 
 

Source:

Cow Bos taurus

 
 

Sequence:

GGLRSLGRKILRAWKKYGPIIVPIIRIG

 
 

Length:

28

 
 

Net charge:

7

 
 

Hydrophobic residue%:

42%

 
 

Boman Index:

0.81 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

CD

 
 

SwissProt ID:

SwissProt ID: P54229  Go to SwissProt

 
 

Activity:

Anti-Gram+ & Gram-, Antiviral, Antifungal, Antiparasitic, Anti-MRSA, Hemolytic, Antibiofilm, Anticancer

 
 

Additional info:

Active against E. coli, S. typhimurium, P. aeruginosa, S. marcescens, S. aureus (MRSA), S. epidermidis, B. megaterium (MIC 0.5-4 uM), C. albicans, and C. neoformans (MIC 4-8 uM). BMAP-28 has broad antimicrobial activities and confers protection in an animal model:mouse of bacterial infection or sepsis (Giacometti A et al. 2004 Crit Care Med 32, 2485-90). Furthermore, BMAP-28 and its isomers demonstrated anti-leishmanial activities against intracellular L. major amastigotes within a macrophage infection model. Interestingly, the D-amino acid form is more active against parasites than either BMAP-28 (the L form) or the sequence reversed form (Lynn MA et al 2011 PLoS Negl Trop Dis. 5(5):e1141). Trucation of the C-terminal tail reduced hemolysis. Of note, a modified peptide (mBMAP-28) was also synthesized by replacing the C-terminal hydrophobic tail (residues 20-28) with a more hydrophilic sequence QATPATRQ also reduced peptide cell selectivity. BMAP-28 is also antiviral (e.g., simplex virus type 1, HSV-1) (Benincasa et al., 2003). Updated 7/2011; 12/2017.

 
       
 

Title:

Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.

 
 

Author:

Skerlavaj B., Gennaro R., Bagella L., Merluzzi L, Risso A, Zanetti M.1996

 
 

Reference:

J. Biol. Chem. 1996; 271: 28375-28381. PubMed.

 
       

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