Antimicrobial Peptide AP00351

     
 

APD ID:

AP00351

 
 

Name/Class:

Citropin 1.1 (UCLL1c; XXA, frog, amphibians, animals)

 
 

Source:

Australian blue mountains tree frog, Litoria citropa

 
 

Sequence:

GLFDVIKKVASVIGGL

 
 

Length:

16

 
 

Net charge:

2

 
 

Hydrophobic residue%:

56%

 
 

Boman Index:

-1.01 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

SwissProt ID: P81835  Go to SwissProt

 
 

Activity:

Anti-Gram+, Antifungal, Anti-MRSA, Antibiofilm, Anticancer

 
 

Additional info:

Active against L. lactis (MIC 6ug/ml), M. luteus, S. epidermidis (MIC 12ug/ml), L. innocua, S. uberis, S. aureus (MRSA, MIC 25ug/ml), B. cereus (MIC 50ug/ml), and B. subtilis (MIC 12.5 ug/ml) (Calabrese AN et al., 2012). The solution structure is an amphipathic alpha-helix with well-defined hydrophobic and hydrophilic regions. Updated 10/2012; 4/2019

 
       
 

Title:

Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1.

 
 

Author:

Wegener KL., Wabnitz PA., Carver JA., Bowie JH., Chia BCS., Wallace JC., Tyler MJ.1999

 
 

Reference:

Eur. J. Biochem. 1999; 265: 627-637. PubMed.

 
       

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