Antimicrobial Peptide AP00276

     
 

APD ID:

AP00276

 
 

Name/Class:

Clavanin A (ClavA; His-rich; urochordates, sea squirts, and sea pork, tunicate, invertebrates, animals; XXA; BBII)

 
 

Source:

invertebrate Styela clava

 
 

Sequence:

VFQFLGKIIHHVGNFVHGFSHVF

 
 

Length:

23

 
 

Net charge:

5

 
 

Hydrophobic residue%:

52%

 
 

Boman Index:

-0.38 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 2MVE   Go to PDB

 
 

Activity:

Anti-Gram+ & Gram-, Anti-MRSA,

 
 

Additional info:

Active against Gram+ S. aureus 930918-3, MRSA (S. aureus 30371, S. aureus 28841), E. faecalis CDC 21, L. monocytogenes EGD (MIC 0.2-3.8 ug/ml), Gram- E. coli ML-35p, E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.4-2.1 ug/ml) (Lee IH et al., 1997). Helices were found between residues Phe2-His11 and Val16-His21 in TFE (Silva et al., 2016). You can rotate, zoom, and view the 3D structure here in the PDB. Being His-rich, the peptide activity can be increased by 16 fold in the presence of Zinc (Zn2+) (Duay et al. 2019). Zinc binding can stabilize the helical structure and enhance memrbane binding. Updated 7/2016; 3/2019.

 
       
 

Title:

Clavanins, alpha-helical antimicrobial peptides from tunicate hemocytes.

 
 

Author:

Lee IH, Zhao C, Cho Y, Harwig SSL, Cooper EL, Lehrer RI.1997

 
 

Reference:

FEBS Lett. 1997; 400:158-162. PubMed.

 
       

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