Antimicrobial Peptide AP00213

     
 

APD ID:

AP00213

 
 

Name/Class:

Tachyplesin III (XXA, UCSS1a; 2S=S; Horseshoe Crab, arachnids, Chelicerata, arthropods, invertebrates, animals)

 
 

Source:

Southeast Asian, Tachypleus gigas

 
 

Sequence:

KWCFRVCYRGICYRKCR

 
 

Length:

17

 
 

Net charge:

7

 
 

Hydrophobic residue%:

47%

 
 

Boman Index:

2.98 kcal/mol

 
 

3D Structure:

Beta

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 6PI3   Go to PDB

 
 

Activity:

Anti-Gram+ & Gram-, Antibiofilm,

 
 

Additional info:

Active against P. aeruginosa ATCC 27853 planktonic cells (MIC 2.0ug/ml) and P. aeruginosa ATCC 27853 adherent cells (MIC 4.0ug/ml). Also active against E. coli DC2 CGSC 7139, E. coli ATCC 25922 (MIC 0.0625-0.5 uM), S. aureus ATCC 25923, and S. aureus ATCC 6538 (MIC 1-8 uM). Two disulfide bridges: 3,16; 7,12. NMR structures of both native and cyclic form have been solved (Vernen F et al., 2019). You can rotate, zoom, and view the 3D structure here in the PDB. Updated 4/2019; 9/2019

 
       
 

Title:

Tachyplesins isolated from hemocytes of Southeast Asian horseshoe crabs (Carcinoscorpius rotundicauda and Tachypleus gigas): identification of a new tachyplesin, tachyplesin III, and a processing intermediate of its precursor.

 
 

Author:

Muta T, Fujimoto T, Nakajima H, Iwanaga S1989

 
 

Reference:

J. Biochem. 1990; 108:261-266

 
       

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