Antimicrobial Peptide AP00180

     
 

APD ID:

AP00180

 
 

Name/Class:

human defensin 5 (HD-5, HD5, DEFA5; intestinal, alpha Defensin; UCSS1a; primates, mammals, animals; BBBH2O; 3S=S; BBL; Derivatives: HD5(1-9))

 
 

Source:

Paneth cells, intestine, Homo sapiens

 
 

Sequence:

ATCYCRTGRCATRESLSGVCEISGRLYRLCCR

 
 

Length:

32

 
 

Net charge:

4

 
 

Hydrophobic residue%:

40%

 
 

Boman Index:

2.6 kcal/mol

 
 

3D Structure:

Beta

 
 

Method:

X-Ray

 
 

SwissProt ID:

PDB ID: 1ZMP   Go to PDB

 
 

Activity:

Anti-Gram+ & Gram-, Antiviral, Antifungal, Anti-toxin, anti-sepsis, Wound healing,

 
 

Additional info:

Constitutively expressed. A reduced expression is observed in ileal Crohn's disease (Wehkamp J et al., 2005). Three disulfide bridges. Structure (nmr+x): for the crystal structure, you can rotate, zoom, and view it here in the PDB. For the NMR structure, you can rotate, zoom, and view it here in the PDB. MOA: The L- and D-forms of HD-5 are equally active against E. coli (D=L) but not S. aureus (Wei G et al 2009 JBC 284: 29180-92). It can bind LPS (Moser et al., 2014). It inhibits non-enveloped BK virus infection by aggregating virions and blocking binding to host cells (JBC 2008; 283: 31125-31132). It also results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures (Lough D, et al., 2013).

Interesting fragments: MOA: HD-5(1-9) can inhibits celluar attachment and entry of human cytomegalovirus (HCMV) (Boffert et al., 2020). HCMV infection causes severe illness in newborns and immunocompromised patients. This peptide may be developed into a viral inhibitor. Importantly. human HD5 Inhibits 2019-nCoV Spike binding to ACE2 based on an unreviewed report (Wang et al., 2020).

Updated 2/2014; 10/2015; 9/2017; 3/2020; 4/2020 GW.

 
       
 

Title:

Paneth cells of the human small intestine express an antimicrobial peptide gene.

 
 

Author:

Jones DE, Bevins CL.1992

 
 

Reference:

J. Biol. Chem. 1992; 267:23216-23225

 
       

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