Antimicrobial Peptide AP00177

     
 

APD ID:

AP00177

 
 

Name/Class:

human neutrophil peptide-2 (HNP-2, HNP2, alpha Defensin, lectin; UCSS1a; primates, mammals, animals; ZZHh, BBS; 3S=S; BBMm)

 
 

Source:

neutrophils; natural killer cells, monocytes; saliva; Homo sapiens

 
 

Sequence:

CYCRIPACIAGERRYGTCIYQGRLWAFCC

 
 

Length:

29

 
 

Net charge:

3

 
 

Hydrophobic residue%:

51%

 
 

Boman Index:

1.17 kcal/mol

 
 

3D Structure:

Beta

 
 

Method:

X-ray

 
 

SwissProt ID:

PDB ID: 1ZMI   Go to PDB

 
 

Activity:

anti-Gram+ & Gram-, antiviral, antifungal, anti-HIV, Chemotactic, Enzyme inhibitor, Cancer cells

 
 

Additional info:

Crystal structures for several HNP2 mutants are available in the PDB. The PDB link below shows the structure with a G16 to D-Ala mutation. You can rotate, zoom, and view the dimeric crystal structure here in the PDB . MOA: It is a lectin and binds to gp120 and CD4, thereby preventing HIV entry (Wang et al. 2004 J Immunol 173: 515-20). Enzyme inhibitor: it inhibits protein kinase C (Charp et al., 1988). Anti-toxin: HNP-1-3 protected mice against the fatal consequences of B. anthracis produces lethal toxin (LeTx). Updated 2/2014; 11/2018.

 
       
 

Title:

Primary structures of three human neutrophil defensins

 
 

Author:

Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI1985

 
 

Reference:

J Clin Invest. 1985 Oct;76(4):1436-9. Pub-Med.

 
       

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