Antimicrobial Peptide AP00171

     
 

APD ID:

AP00171

 
 

Name/Class:

Metchnikowin (Mtk-1, Pro-rich; insects, arthropods, invertebrates, animals)

 
 

Source:

Common fruit fly, Drosophila melanogaster

 
 

Sequence:

HRHQGPIFDTRPSPFNPNQPRPGPIY

 
 

Length:

26

 
 

Net charge:

2

 
 

Hydrophobic residue%:

15%

 
 

Boman Index:

2.9 kcal/mol

 
 

3D Structure:

Rich

 
 

SwissProt ID:

SwissProt ID: Q24395  Go to SwissProt

 
 

Activity:

Anti-Gram+, Antifungal, Antiparasitic, Antimalarial,

 
 

Additional info:

Rich in Proline. This peptide is induced via the TOLL pathway. Active against M. luteus (MIC 0.5-1 uM), and N. crassa (MIC 0.5-1.0 uM). It showed significant (P < 0.001) inhibitory activity against the blood-stage P. falciparum parasite (Tonk et al. 2019). Transgenic plants: Insect peptide metchnikowin confers on barley a selective capacity for resistance to fungal ascomycetes pathogens (J Exp Bot. 2009;60(14):4105-14). Updated 4/2017; 5/2019.

 
       
 

Title:

Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties.

 
 

Author:

Levashina EA, Ohresser S, Bulet P, Reichhart J-M, Hetru C, Hoffmann JA.1995

 
 

Reference:

Eur J Biochem. 1995 Oct 15;233(2):694-700. PubMed.

 
       

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