Antimicrobial Peptide AP00161

     
 

APD ID:

AP00161

 
 

Name/Class:

Dermaseptin-S5 (DRS-S5; Dermaseptin S5, DRS S5; UCLL1; frog, amphibians, animals; ZZP)

 
 

Source:

Sauvage's leaf frog, Phyllomedusa sauvagii, South America

 
 

Sequence:

GLWSKIKTAGKSVAKAAAKAAVKAVTNAV

 
 

Length:

29

 
 

Net charge:

6

 
 

Hydrophobic residue%:

55%

 
 

Boman Index:

0.18 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

SwissProt ID: P80281  Go to SwissProt

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal, candidacidal, Antiparasitic,

 
 

Additional info:

Active against A. caviae IP67-16T (MIC 35 uM), E. coli IP76-24 (MIC 35 uM), E. faecalis IP103214 (MIC 40 uM), S. aureus IP76-25 (MIC 2 uM), N. brasiliensis IP118079 (MIC 40 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 1uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 20 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 (MIC 30 uM). Based on the primary structure, it can be fitted to a class L amphipathic alpha helix which places all K on the polar face. Updated 5/2020

 
       
 

Title:

The Vertebrate Peptide Antibiotics Dermaseptins Have Overlapping Structural Features but Target Specific Microorganisms

 
 

Author:

Mor A, Hani K, Nicolas P. 1994

 
 

Reference:

J Biol Chem. 1994;269(50):31635-31641.PubMed.

 
       

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