Antimicrobial Peptide AP00160

     
 

APD ID:

AP00160

 
 

Name/Class:

Dermaseptin-S4 (DRS-S4; Dermaseptin S4, DRS S4, DS4, Dermaseptin IV; DS IV; UCLL1; frog, amphibians, animals; ZZHa; ZZP; ZZS; BBL)

 
 

Source:

Sauvage's leaf frog, Phyllomedusa sauvagii, South America

 
 

Sequence:

ALWMTLLKKVLKAAAKAALNAVLVGANA

 
 

Length:

28

 
 

Net charge:

4

 
 

Hydrophobic residue%:

71%

 
 

Boman Index:

-0.91 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 2DD6   Go to PDB

 
 

Activity:

Anti-Gram+ & Gram-, Antiviral, Antifungal, candidacidal, Antiparasitic, Spermicidal, Anti-HIV, anti-sepsis, Antimalarial, Hemolytic,

 
 

Additional info:

Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 4 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10-20 uM), N. brasiliensis IP118079 (MIC 10 uM), S. cerevisiae IP118079 (MIC 20 uM), C. albicans IP884-65, IP886-65 (MIC 20 uM), C. neoformans IP960-67 and IP962-67 (MIC 1-2 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 20 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 20-30 uM). Active against S. aureus (MIC 13-29ug/ml), C. albicans (MIC 11.5-26ug/ml) and N. gonorrheae (MIC 51-103ug/ml). It also showed activities against P. falciparum (antimalarial) as well as human sperm. Based on the primary structure, it can be fitted to a class L amphipathic alpha helix which places all K on the polar face. The N-terminal region is responsible for both oligomerization and hemolytic activity. NMR structures of two derivatives have been solved [2DD6 for K4-S4(1-13) and 2DCX for NC12-K4S4(1-13)]. The 3D structures remain the same. You can rotate, zoom, and view the 2DD6 structure here in the PDB. Sequence has been corrected based on the original paper. 3/2015 GW; 4/2019 C Wang; Updated 5/2020 GW.

 
       
 

Title:

The Vertebrate Peptide Antibiotics Dermaseptins Have Overlapping Structural Features but Target Specific Microorganisms

 
 

Author:

Mor A, Hani K, Nicolas P. 1994

 
 

Reference:

J Biol Chem. 1994;269(50):31635-31641.PubMed.

 
       

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