Antimicrobial Peptide AP00159

     
 

APD ID:

AP00159

 
 

Name/Class:

Dermaseptin-S3 (DRS-S3; Dermaseptin S3, DRS S3, DS3, Dermaseptin III; DS III; UCLL1; XXA; frog, amphibians, animals; ZZP)

 
 

Source:

Sauvage's leaf frog, Phyllomedusa sauvagii, South America

 
 

Sequence:

ALWKNMLKGIGKLAGKAALGAVKKLVGAES

 
 

Length:

30

 
 

Net charge:

6

 
 

Hydrophobic residue%:

53%

 
 

Boman Index:

-0.25 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

SwissProt ID: P80279  Go to SwissProt

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal, candidacidal, Antiparasitic, Antimalarial,

 
 

Additional info:

Active against A. caviae IP67-16T (MIC 1 uM), E. coli IP76-24 (MIC 2.5 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 10 uM), N. brasiliensis IP118079 (MIC 5 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 40 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 20-30 uM), A. simii J43 (MIC 10 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 10-20 uM). Active against P. falciparum (Ghosh et al., 1998). Based on the primary structure, it can be fitted to a class L amphipathic alpha helix which places all K on the polar face. DS-S3(1-16) is active against S. cerevisiae (Coote et al., 1997). MOA:fungi: Induced diagnostic markers of yeast apoptosis: the appearance of reactive oxygen species and fragmentation of nuclear DNA (Morton et al., 2007). Updated 5/2020

 
       
 

Title:

The Vertebrate Peptide Antibiotics Dermaseptins Have Overlapping Structural Features but Target Specific Microorganisms

 
 

Author:

Mor A, Hani K, Nicolas P. 1994

 
 

Reference:

J Biol Chem. 1994;269(50):31635-31641.PubMed.

 
       

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