Antimicrobial Peptide AP00157

     
 

APD ID:

AP00157

 
 

Name/Class:

Dermaseptin-S1 (DRS-S1; Dermaseptin I; DS I; Dermaseptin S1, DRS S1, UCLL1; frog, amphibians, animals; ZZS; ZZHa_t; ZZP)

 
 

Source:

Sauvage's leaf frog, Phyllomedusa sauvagii, South America

 
 

Sequence:

ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ

 
 

Length:

34

 
 

Net charge:

3

 
 

Hydrophobic residue%:

50%

 
 

Boman Index:

0.16 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

CD

 
 

SwissProt ID:

SwissProt ID: P80277  Go to SwissProt

 
 

Activity:

Anti-Gram+ & Gram-, Antiviral, Antifungal, candidacidal, Antiparasitic, Spermicidal, Anti-HIV,

 
 

Additional info:

Active against A. caviae IP67-16T (MIC 0.5 uM), E. coli IP76-24 (MIC 1 uM), E. faecalis IP103214, S. aureus IP76-25 (MIC 5 uM), N. brasiliensis IP118079 (MIC 35 uM), S. cerevisiae IP118079 (MIC 5 uM), C. albicans IP884-65, IP886-65 (MIC 10 uM), C. neoformans IP960-67 and IP962-67 (MIC 0.5-1 uM), M. canis IP1194 (MIC 15 uM), T. rubrum IP2043-92 (MIC 35 uM), T. metagrophytes IP877-71 (MIC 20 uM), A. simii IP1063-74, mutant (MIC 30 uM), A. simii J43 (MIC 15 uM), A. niger IP218-53 and A. fumigatus IP1025-70 (MIC 30 uM). Active against S. aureus and E. coli (MIC 12 uM). The peptide is active against Leishmania major (Perez-Cordero JJ et al. 2011 Peptides 32 (4), 683-90). Also showed spermicidal activity. A segment corresponding to residue 1-18 was found to have a comparable activity to the parent peptide (JBC 1994; 269: 1934-39). Helix in TFE. This peptide could inhibit HIV infection at a concentration that is also toxic to T cells (J Virol 2005; 79:11598-11606). Ref updated 7/2016; Jan2020; 5/2020; 7/2020

 
       
 

Title:

Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin

 
 

Author:

Mor A, Nguyen VH, Delfour A, Migliore-Samour D, Nicolas P.1991

 
 

Reference:

Biochemistry. 1991;30(36):8824-8830. doi:10.1021/bi00100a014.PubMed.

 
       

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