Antimicrobial Peptide AP00152

     
 

APD ID:

AP00152

 
 

Name/Class:

Tritrpticin (tritrypticin, SN13, Trp-rich; porcine cathelicidin; mammals, animals; SeqAR; Derivatives)

 
 

Source:

synthetic fragment of porcine cathelicidin.

 
 

Sequence:

VRRFPWWWPFLRR

 
 

Length:

13

 
 

Net charge:

4

 
 

Hydrophobic residue%:

53%

 
 

Boman Index:

2.9 kcal/mol

 
 

3D Structure:

nonhelixbeta

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 1D6X   Go to PDB

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal, Hemolytic,

 
 

Additional info:

Predicted from cDNA and the exact form is yet to be identified. Active against E. coli, P. aeruginosa, K. pneumonia, S. epidermidis, P. mirabilis, and Streptococcus group D as well as A. fumigatus. Consecutive arginine residues on both the N- and C-terminals of this peptide appears to be essential for antibacterial activity of this synthetic peptide corresponding a portion of porcine C-terminal AMP sequence. The peptide remained active against bacteria after deleting the N-terminal 6 residues (Nagpal et al 1999 J Biol Chem 274: 23296-23304). A unique strucure fold was determined by Schibli DJ, et al. (1999) Biochemistry 38: 16749. You can rotate, zoom, and view the 3D structure here in the PDB . Updated Jan2013; 2/2014; 6/2016.

 
       
 

Title:

Antimicrobial activity of a 13 amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides

 
 

Author:

Lawyer C, Pai S, Watabe M, Borgia P, Mashimo T, Eagleton L, Watabe K.1996

 
 

Reference:

FEBS Lett. 1996 Jul 15;390(1):95-8.PubMed

 
       

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