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APD ID: |
AP00150 |
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Name: |
Indolicidin (XXA, cow cathelicidin, BBN; BBPP/BBII; ZZHa. Variants: CP-11, MBI-549, Omiganan pentahydrochloride (formerly MBI 226), clinical, animals; BBL; JJsn) |
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Source: |
bovine neutrophils, Bos taurus |
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Sequence: |
ILPWKWPWWPWRR |
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Length: |
13 |
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Structure: |
Rich |
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Method: |
NMR |
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Additional info: |
MOA: It targets DNA of HIV (Nucleic Acids Res 2006; 34: 5157-65). 3D structures of the peptide bound to SDS or DPC micelles were solved by solution NMR (see Rosek A et al. 2000. Biochemistry 39: 15765). Antimicrobial activity still remains with with P to A substitution. For CP-11, see Antimicrob Agents Chemother. 1997 Apr;41(4):771-5. The sequence of MBI 226 is RGGLCYCRGRFCVCVGR and it has activity against bacteria and fungi. This peptide showed synergistic effect with protegrin-1 against P. aeruginosa and E. coli (Yan H & Hancock REW 2001 Antimicrob Agents Chemother 45: 1558-60). |
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Crucial residues: |
C-terminal amide. |
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Activity: |
Gram+ & Gram-, Virus, Fungi, Mammalian cells, |
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Net charge: |
3 |
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Hydrophobic residue%: |
53% |
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Boman Index: |
1.06 kcal/mol |
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SwissProt ID: |
PDB ID:
1G89
Go to PDB
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Reference: |
J Biol Chem 1992; 267: 4292-4295 |
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Author: |
Selsted ME et al. Cullor JS |
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Title: |
Indolicidin, a novel bactericidal tridecapeptide amide from neutraphils |
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