Antimicrobial Peptide AP00150

     
 

APD ID:

AP00150

 
 

Name/Class:

Indolicidin (IR13; Tet083; XXA, Trp-rich, bovine cathelicidin, cattle, ruminant, mammals; animals; BBN; BBPP/BBII; Derivatives: CP-11, MBI-549, Omiganan pentahydrochloride (formerly MBI 226; MBI-226

 
 

Source:

bovine neutrophils, Bos taurus

 
 

Sequence:

ILPWKWPWWPWRR

 
 

Length:

13

 
 

Net charge:

4

 
 

Hydrophobic residue%:

53%

 
 

Boman Index:

1.06 kcal/mol

 
 

3D Structure:

nonhelixbeta

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 1G89   Go to PDB

 
 

Activity:

Anti-Gram+ & Gram-, Antiviral, Antifungal, Anti-HIV, Anti-MRSA, Hemolytic, Antibiofilm, Wound healing,

 
 

Crucial residues:

C-terminal amide.

 
 

Additional info:

Active against S. aureus ATCC29213 (MIC 3 uM), S. aureus NCDC-0111 (MIC 1.5 uM), L. monocytogenes ATCC-19111 (MIC 6 uM), B. cereus NCDC-0240 (MIC 0.8 uM), P. aeruginosa ATCC-27853 (MIC 25 uM), P. aeruginosa NCDC-0105 (MIC 12.5 uM), S. typhimurium ATCC-14028 (MIC 12.5 uM), E. coli MTCC-0723 (MIC 0.8 uM), and A. johnsonii NCDC-0072 (MIC 6 uM) (Brahma B et al., 2015). Also active against Herpes Simplex Virus (HSV-1 and HSV-2) (Yasin et al., 2000). Interestingly, immobilization of the peptide (immobilized) onto quantum dots (QDs) enhanced peptide activity and decreased toxicity (Galdiero et al., 2016). In addition, it also has antibiofilmB activity of MRSA (Mataraci and Dosler, 2012). You can rotate, zoom, and view the 3D structure here in the PDB. Indolicidin showed efficacy in an animal model: mouse (Ghiselli R et al 2008 Crit Care Med 36: 240-5). Wound healing/animal model:rats: Omiganan-alone and combined with imipenem-was associated with a better control of inflammatory parameters than imipenem alone. Indolicidin derivatives were subjected to clinical trials. Updated 6/2015; 12/2015; 9/2016; 11/2017.

 
       
 

Title:

Indolicidin, a novel bactericidal tridecapeptide amide from neutraphils

 
 

Author:

Selsted ME, Novotny MJ, Morris WL, Tang YQ, Smith W, Cullor JS.1992

 
 

Reference:

J Biol Chem. 1992 Mar 5;267(7):4292-5. Pub-Med

 
       

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