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APD ID: |
AP00146 |
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Name: |
Melittin (XXA, insect, ZZHa, StrAR, invertebrates, animals; BBL) |
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Source: |
Honeybee venom, Apis mellifera (also A. florea, A. cerana) |
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Sequence: |
GIGAVLKVLTTGLPALISWIKRKRQQ |
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Length: |
26 |
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Structure: |
Helix |
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Method: |
X-Ray |
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Additional info: |
It forms a tetramer at high peptide concentrations or high salt concentrations. Melittin contains one alpha helix (residues 2-25) with a bend between residues 11-15. A P14A mutation removed the bend but became 2.5-fold more hemolytic. MOA: It inhibits HIV by suppressing viral gene expression (J Gen Virol 1998; 79:731-40). |
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Crucial residues: |
K7 and W19 are important for activity. |
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Activity: |
Gram+ & Gram-, Virus, Fungi, Mammalian cells, Cancer cells |
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Net charge: |
5 |
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Hydrophobic residue%: |
46% |
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Boman Index: |
0.57 kcal/mol |
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SwissProt ID: |
PDB ID:
2MLT
Go to PDB
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Reference: |
FEBS Lett 1973; 33: 241-244 |
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Author: |
Kreil G |
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Title: |
Structure of melittin isolated from two species of honey bees |
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