Antimicrobial Peptide AP00134

     
 

APD ID:

AP00134

 
 

Name/Class:

Cecropin P1 (CP1, roundworms, nematode; invertebrates, animals; revisited; BBL)

 
 

Source:

Ascaris suum (living in pig)

 
 

Sequence:

SWLSKTAKKLENSAKKRISEGIAIAIQGGPR

 
 

Length:

31

 
 

Net charge:

5

 
 

Hydrophobic residue%:

35%

 
 

Boman Index:

1.85 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

SwissProt ID: P14661  Go to SwissProt

 
 

Activity:

Anti-Gram+ & Gram-,

 
 

Additional info:

Initially thought from pig (see the ref), this AMP is actually synthesized by a roundworm in pigs (Andersson M et al 2003 Cell Mol Life Sci 60: 599-606). Active against Gram+ S. aureus 930918-3 (MIC 22.2 ug/ml), E. faecalis CDC 21, L. monocytogenes EGD (MIC 3-9.4 ug/ml), Gram- E. coli ML-35p, E. coli mcr 106, E. coli BAS 849, S. typhimurium 14028S, S. typhimurium 7953S, K. pneumoniae 2270, P. aeruginosa SBI-N, P. aeruginosa MR2123, and P. aeruginosa MR3007 (MIC 0.3-0.5 ug/ml) (Lee IH et al., 1997). Also Active against colistin-susceptible A. baumannii (Vila-Farres X et al Clin Microb Infect in press) MIC=1.6 ug/ml but less active against the resistant strain (MIC >25 ug/ml). The structure of the mammalian antibacterial peptide cecropin P1 in solution, was determined by proton-NMR (Sipos D et al. Eur. J. Biochem. 1992; 209:163-169). Transgenic plants: expression of this peptide in tobacco increases resistance of the plant to microbial pathogens (Genetika. 2009 Aug;45(8):1061-6). Updated 2/2010; 12/2011. ref updated 7/2013; 7/2016.

 
       
 

Title:

Antibacterial peptides from pig intestine: isolation of a mammalian cecropin

 
 

Author:

Lee JY, Boman A, Sun CX, Andersson M, Jörnvall H, Mutt V, Boman HG.1989

 
 

Reference:

Proc Natl Acad Sci U S A. 1989 Dec;86(23):9159-62.PubMed.

 
       

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