Antimicrobial Peptide AP00121

     
 

APD ID:

AP00121

 
 

Name/Class:

RANATUERIN 2P (Ranatuerin-2P, frog, amphibians, animals; ZZHa_t; XXU; 1S=S, UCSS1a)

 
 

Source:

North American frog, Rana pipiens , ALSO: the Oregon spotted frog Rana pretiosa

 
 

Sequence:

GLMDTVKNVAKNLAGHMLDKLKCKITGC

 
 

Length:

28

 
 

Net charge:

3

 
 

Hydrophobic residue%:

46%

 
 

Boman Index:

0.78 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

SwissProt ID: P82847  Go to SwissProt

 
 

Activity:

anti-Gram+ & Gram-, antiviral, anti-HIV,

 
 

Additional info:

Disulfide bridge: C22,C27. Active against S. aureus (MIC 50 uM), E. coli (MIC 13 uM), and C. albicans (MIC 67 uM). This peptide could inhibit HIV infection at a concentration that is also toxic to T cells (J Virol 2005; 79:11598-11606). Found in multiple species. Updated 3/2015.

 
       
 

Title:

Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.

 
 

Author:

Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.2000

 
 

Reference:

Eur J Biochem. 2000 Feb;267(3):894-900. PubMed.

 
       

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