Antimicrobial Peptide AP00101

     
 

APD ID:

AP00101

 
 

Name/Class:

Temporin L (temporin-1Tl; temporin-Tl; TL; XXA, UCLL1c; frog, amphibians, animals; BBL; JJsn; BBMm)

 
 

Source:

European common frog, Rana temporaria

 
 

Sequence:

FVQWFSKFLGRIL

 
 

Length:

13

 
 

Net charge:

3

 
 

Hydrophobic residue%:

61%

 
 

Boman Index:

-0.12 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

SwissProt ID: P57104  Go to SwissProt

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal, Antiparasitic, Hemolytic, Anticancer

 
 

Additional info:

C-terminal amidated. Active against parasites L. mexicana (Molecules. 2015 Feb 6;20(2):2775-85). Giacometti et al (2006) found that the peptide showed the high activity when used with beta-lactams. As the most active peptide in the temporin family, it may form pore-like openings on cellular membranes (Biochem J 2002; 368: 91-100). A helical structure was found by NMR studies in SDS and DPC micelles (Carotenuto et al. 2008. J Med Chem 51: 2354-62). Temporin L showed synergism with temporins A & B to inhibit LPS aggregation (J Biol Chem. 2006 Sep 29;281(39):28565-74). Updated Jan2017.

 
       
 

Title:

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

 
 

Author:

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.1996

 
 

Reference:

Eur J Biochem. 1996 Dec 15;242(3):788-92. PubMed.

 
       

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