Antimicrobial Peptide AP00095

     
 

APD ID:

AP00095

 
 

Name/Class:

Temporin B (temporin-1Tb; temporin-Tb; TB; Leu-rich; XXA, UCLL1c; frog, amphibians, animals; ZZP)

 
 

Source:

European common frog, Rana temporaria

 
 

Sequence:

LLPIVGNLLKSLL

 
 

Length:

13

 
 

Net charge:

2

 
 

Hydrophobic residue%:

61%

 
 

Boman Index:

-1.83 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 6GIL   Go to PDB

 
 

Activity:

anti-Gram+ & Gram-, antiviral, antiparasitic, Chemotactic, Antibiofilm,

 
 

Additional info:

C-terminal amidated. Active against B. megaterium Bm11, S. aureus Cowan I (MIC , Y. pseudotubercolosis, S. pyogenes beta hem. group A (MIC 2.8-7 uM), E. coli D21 (MIC 21 uM), and C. albicans (MIC 4 uM), including parasites L. donovani and L. mexicana (Molecules. 2015 Feb 6;20(2):2775-85; J Biol Chem. 2005 Jan 14;280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (12-48 uM), and A. baumannii (MIC (24 uM). The D-form was found to be more active and stable than the L-form (D>L; Herin OH et al 2000 Antimicrob Agents Chemother 44:68-72). This peptide has antibiofilm ability against S. epidermidis (Maisetta et al., 2016). Temporin B also inhibits herpes simplex virus type 1 (HSV-1) infection (Marcocci ME et al., 2018). It can damage viral envelope and inflences the attachment, the entry of the virus into the host cell as well as the following post infection phase. In addiiton, the peptide can promote cell migration (chemotactic) (Di Grazia A et al., 2014).You can rotate, zoom, and view the 3D structure here in the PDB. Updated 2/23/2012 GW & BM; 3/2015; Jan2017; 11/2017; 4/2018; 8/2018 GW.

 
       
 

Title:

Temporins, antimicrobial peptides from the European red frog Rana temporaria.

 
 

Author:

Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.1996

 
 

Reference:

Eur J Biochem. 1996 Dec 15;242(3):788-92. PubMed.

 
       

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