Antimicrobial Peptide AP00081

     
 

APD ID:

AP00081

 
 

Name/Class:

Esculentin-1A (frog, amphibians, animals; XXU; 1S=S, UCSS1a; Derivatives: Esc(1-21))

 
 

Source:

Edible frog, Pelophylax lessonae/ridibundus, old nameRana esculenta , Europe

 
 

Sequence:

GIFSKLAGKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC

 
 

Length:

46

 
 

Net charge:

5

 
 

Hydrophobic residue%:

43%

 
 

Boman Index:

0.62 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

SwissProt ID: P40843  Go to SwissProt

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal,

 
 

Additional info:

Active against E. coli D21, B. megaterium BmII, S. aureus Cowan 1, F? aeruginosab ATCC15692, C. albican, S. cerevisiae (MIC 0.1-0.9 uM). It devoids hemolytic activity till 100 uM. Its N-terminal 21-residue fragment ESc(1-21) Showed a wide specrum activity against both planktonic and biofilm form of Gram- P. aeruginosa, largely via membrane pertubation. Thhis activity is preserved in biological fluids. In addition, Esc(1-21) promote human keratinocyte migration thro interaction with the EGF receptor. This cell migration can be important for wound healing (Di Grazia A et al., 2015). Esculentin-1a derived peptides residue 1-21 kill Pseudomonas aeruginosa biofilm on soft contact lenses and retain antibacterial activity upon immobilization to the lens surface (Casciaro et al., 2017). Updated 10/2015; Jan2018.

 
       
 

Title:

Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.

 
 

Author:

Simmaco M, Mignogna G, Barra D, Bossa F.1994

 
 

Reference:

J Biol Chem. 1994 Apr 22;269(16):11956-61. PubMed.

 
       

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