Antimicrobial Peptide AP00073

     
 

APD ID:

AP00073

 
 

Name/Class:

Brevinin-1E (frog, amphibians, animals; XXU; 1S=S, UCSS1a)

 
 

Source:

Edible frog, Rana esculenta , Europe

 
 

Sequence:

FLPLLAGLAANFLPKIFCKITRKC

 
 

Length:

24

 
 

Net charge:

4

 
 

Hydrophobic residue%:

62%

 
 

Boman Index:

-0.48 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

SwissProt ID: P32412  Go to SwissProt

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal, candidacidal, anti-diabetes, Hemolytic,

 
 

Crucial residues:

The Cys residue?

 
 

Additional info:

Active against E. coli D21 (MIC 1.8 uM), B. megaterium BmII, S. aureus Cowan 1 (MIC 0.4-0.6 uM), P. aeruginosa ATCC15692 (MIC 30.6 uM), C. albicans, and S. cerevisiae (MIC 3.8-4.7 uM). It is hemolytic at 0.5 uM. The C-terminal S-S-linked loop resembles the lipid A binding hexapeptide ring domain of polymyxin B. This peptide promotes insulin secretion in acute 20-min incubations with glucose responsive BRIN-BD11 cells (Marenah L et al., 2006), thereby of interest for type 2 diabetes (T2D). Updated 10/2015; 12/2018.

 
       
 

Title:

Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.

 
 

Author:

Simmaco M, Mignogna G, Barra D, Bossa F.1994

 
 

Reference:

J Biol Chem. 1994 Apr 22;269(16):11956-61. PubMed.

 
       

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