Antimicrobial Peptide AP00067

     
 

APD ID:

AP00067

 
 

Name/Class:

Bombolitin II (BII, Bombolitin 2, insects, arthropods, invertebrates, animals; XXA)

 
 

Source:

American common bumblebee, Megabombus pennsylvanicus

 
 

Sequence:

SKITDILAKLGKVLAHV

 
 

Length:

17

 
 

Net charge:

4

 
 

Hydrophobic residue%:

52%

 
 

Boman Index:

-0.07 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

SwissProt ID: P07493  Go to SwissProt

 
 

Activity:

Antifungal, Hemolytic,

 
 

Additional info:

The W analog substantially influenced S. cerevisiae growth rates (Roberson et al. 2019 Biophysical J. 116:1064-74). the petpide is highly hemolytic to pig erythrocyte (ED50 3.9 ug/ml), this membrane active peptide is also helical in SDS micelles. updated 5/2020

 
       
 

Title:

Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus.

 
 

Author:

Argiolas A, Pisano JJ1985

 
 

Reference:

J Biol Chem. 1985 Feb 10;260(3):1437-44. PubMed.

 
       

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