Antimicrobial Peptide AP00062

     
 

APD ID:

AP00062

 
 

Name/Class:

Maximin 5 (UCLL1; toad, amphibians, animals)

 
 

Source:

Chinese red belly toad, Bombina maxima , Yunnan, China, Asia

 
 

Sequence:

SIGAKILGGVKTFFKGALKELASTYLQ

 
 

Length:

27

 
 

Net charge:

3

 
 

Hydrophobic residue%:

44%

 
 

Boman Index:

-0.07 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

SwissProt ID: P83084  Go to SwissProt

 
 

Activity:

anti-Gram+ & Gram-, antiviral, antifungal, anti-HIV, Cancer cells

 
 

Additional info:

Active against S. aureus ATCC2592, B. pyocyaneus CMCCB10104, B. megatherium, B. dysenterium, K. pneumoniae, C. albicans ATCC2002, A. favus IFFI4015, and P. uticale IFFI2001 (MIC 3.6-12 uM). active against cancer cells C8166 (IC50 34 ug/ml). It also has anti-HIV and spermicidal effects. EC50 against HIV-1 is 39.8 ug/ml (cell selectivity index 0.88) (Lai R et al., 2012). Updated 2/2012; 12/2015 GW.

 
       
 

Title:

Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.

 
 

Author:

Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002.

 
 

Reference:

Peptides 2002; 23:427-435. PubMed.

 
       

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