Antimicrobial Peptide AP00060

     
 

APD ID:

AP00060

 
 

Name/Class:

Maximin 3 (UCLL1; toad, amphibians, animals; ZZHa; ZZS)

 
 

Source:

Chinese red belly toad, Bombina maxima , Yunnan, China, Asia

 
 

Sequence:

GIGGKILSGLKTALKGAAKELASTYLH

 
 

Length:

27

 
 

Net charge:

4

 
 

Hydrophobic residue%:

40%

 
 

Boman Index:

-0.02 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

SwissProt ID: P83082  Go to SwissProt

 
 

Activity:

anti-Gram+ & Gram-, antiviral, antifungal, Spermicidal, anti-HIV, Hemolytic, Cancer cells

 
 

Additional info:

Active against E. coli ATCC25922, S. aureus ATCC2592, B. pyocyaneus CMCCB10104, B. megatherium, B. dysenterium, K. pneumoniae, and C. albicans ATCC2002 (MIC 0.9-15 uM). It also has anti-HIV and spermicidal effects. active against cancer cells C8166, Molt-4, BIU-4, and T24 (IC50 11-28 ug/ml). EC50 against HIV-1 is 1.5 ug/ml (cell selectivity index 7.6) (Lai R et al., 2012). 3D structure, determined in 50% TFE by 2D NMR, revealsed a helical region covering reisdues 1-22 and a disordered structure at the C-terminus (Benetti et al., 2019). Updated 2/2012; 12/2015; 2/2019 GW.

 
       
 

Title:

Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.

 
 

Author:

Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002.

 
 

Reference:

Peptides 2002; 23:427-435. PubMed.

 
       

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