Antimicrobial Peptide AP00058

     
 

APD ID:

AP00058

 
 

Name/Class:

Maximin 1 (UCLL1c; XXA; toad, amphibians, animals; ZZS)

 
 

Source:

Chinese red belly toad, Bombina maxima , Yunnan, China, Asia

 
 

Sequence:

GIGTKILGGVKTALKGALKELASTYAN

 
 

Length:

27

 
 

Net charge:

4

 
 

Hydrophobic residue%:

40%

 
 

Boman Index:

0.05 kcal/mol

 
 

3D Structure:

Unknown

 
 

SwissProt ID:

SwissProt ID: P83080  Go to SwissProt

 
 

Activity:

anti-Gram+ & Gram-, antiviral, antifungal, Spermicidal, anti-HIV, Mammalian cells, Cancer cells

 
 

Additional info:

Active against E. coli ATCC25922, S. aureus ATCC2592, B. pyocyaneus CMCCB10104, B. megatherium (MIC 19.5 ug/ml), K. pneumoniae (MIC 9 ug/ml), B. dysenterium, and C. albicans ATCC2002 (MIC 3 uM). It also has spermicidal effect. active against cancer cells C8166, Molt-4, BIU-4, and T24 (IC50 15-35 ug/ml). EC50 against HIV-1 is 21.4 ug/ml (Lai R et al., 2012). Updated 2/2012; 12/2015; GW.

 
       
 

Title:

Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.

 
 

Author:

Lai R, Zheng Y-T, Shen J-H, Liu GJ, Liu H, Lee W-H, Tang S-Z., Zhang Y.2002.

 
 

Reference:

Peptides 2002; 23:427-435. PubMed.

 
       

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