Antimicrobial Peptide AP00056

     
 

APD ID:

AP00056

 
 

Name/Class:

Bombinin H4 (UCLL1c; toad, amphibians, XXA, XXD, animals; inactive bombinin H6)

 
 

Source:

Yellow-bellied toad, Bombina variegata L, Europe

 
 

Sequence:

ILGPVLGLVGSALGGLLKKI

 
 

Length:

21

 
 

Net charge:

3

 
 

Hydrophobic residue%:

52%

 
 

Boman Index:

-1.97 kcal/mol

 
 

3D Structure:

Helix

 
 

Method:

NMR

 
 

SwissProt ID:

PDB ID: 2AP8   Go to PDB

 
 

Activity:

Anti-Gram+ & Gram-, Antifungal, candidacidal, Antiparasitic, Hemolytic,

 
 

Additional info:

Position 1 is represented with I (58%, and 42% are L). The second position is D-aILe, represented with L to be distinct. Active against E. coli D21 (LC 4.8 uM) and S. aureus Cowan 1(LC 3.3 uM). Active also against Gram- Y. pseudotuberculosis YPIII (LC 8.2 uM), P. syringae pv tabaci (8.2 uM), E. agglomerans Bo-1S (11.3 uM), Gram+ B. megaterium Bm11 (0.8 uM), S. lentus (0.60 uM), M. luteus (0.2 uM), fungi C. albicans ATCC 10231 (1.6 uM), C. guiller-mondii (0.7 uM), C. tropicalis (0.6 uM) (Mangoni ML et al. 2007). The residue at position-2 is a D-amino acid (D-alloisoleucine). In addition, the relative abundance of the amino acid at position 1 is Ile (58%) and Leu (42%). Structure was determined in SDS or DPC (Toxicon. 2008; 52(2):246-54). You can rotate, zoom, and view the 3D structure here in the PDB . (MIC data provided by Chunfeng Wang). Updated 9/2017; 3/2018; 5/2020.

 
       
 

Title:

Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.

 
 

Author:

Mignogna G, Simmaco M, Kreil G, Barra D.1993

 
 

Reference:

EMBO J. 1993; 12:4829-4832. PubMed.

 
       

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